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GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase [ Homo sapiens (human) ]

Gene ID: 2618, updated on 2-Nov-2024

Summary

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Official Symbol
GARTprovided by HGNC
Official Full Name
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetaseprovided by HGNC
Primary source
HGNC:HGNC:4163
See related
Ensembl:ENSG00000159131 MIM:138440; AllianceGenome:HGNC:4163
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AIRS; GARS; PAIS; PGFT; PRGS; GARTF
Summary
The protein encoded by this gene is a trifunctional polypeptide. It has phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase activity which is required for de novo purine biosynthesis. This enzyme is highly conserved in vertebrates. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 13.5), lymph node (RPKM 11.6) and 25 other tissues See more
Orthologs
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Genomic context

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See GART in Genome Data Viewer
Location:
21q22.11
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (33503931..33542893, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (31885765..31924746, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (34876238..34915198, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene RPS5 pseudogene 3 Neighboring gene DnaJ heat shock protein family (Hsp40) member C28 Neighboring gene basic transcription factor 3 pseudogene 6 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr21:34903402-34904601 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13260 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:34914753-34915484 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13261 Neighboring gene SON DNA and RNA binding protein Neighboring gene microRNA 6501 Neighboring gene DNA replication fork stabilization factor DONSON Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:34960679-34961178

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Biological and structural evaluation of 10R- and 10S-methylthio-DDACTHF reveals a new role for sulfur in inhibition of glycinamide ribonucleotide transformylase. Connelly S, et al. Biochemistry, 2013 Jul 30. PMID 23869564, Free PMC Article
  2. Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid. Zhang Y, et al. Biochemistry, 2003 May 27. PMID 12755606
  3. The apo and ternary complex structures of a chemotherapeutic target: human glycinamide ribonucleotide transformylase. Dahms TE, et al. Biochemistry, 2005 Jul 26. PMID 16026156
  4. Human glycinamide ribonucleotide transformylase: active site mutants as mechanistic probes. Manieri W, et al. Biochemistry, 2007 Jan 9. PMID 17198385, Free PMC Article
  5. Phylogenetic analysis and in silico characterization of the GARS-AIRS-GART gene which codes for a tri-functional enzyme protein involved in de novo purine biosynthesis. Banerjee D, et al. Mol Biotechnol, 2009 Jul. PMID 19301155

See all (160) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GART Functions as a Novel Methyltransferase in the RUVBL1/beta-Catenin Signaling Pathway to Promote Tumor Stemness in Colorectal Cancer.
    Title: GART Functions as a Novel Methyltransferase in the RUVBL1/β-Catenin Signaling Pathway to Promote Tumor Stemness in Colorectal Cancer.
  2. VGLL3 increases the dependency of cancer cells on de novo nucleotide synthesis through GART expression.
    Title: VGLL3 increases the dependency of cancer cells on de novo nucleotide synthesis through GART expression.
  3. The transcriptome profile of human trisomy 21 blood cells.
    Title: The transcriptome profile of human trisomy 21 blood cells.
  4. GART expression is up-regulated in patients with active colitis.
    Title: GART mediates the renewal of intestinal epithelial barrier via p38/p53/PUMA cascade in colitis.
  5. The minor A allele of rs7279549 of GART is a functional risk factor for congenital heart disease in Shandong population.
    Title: Association of genetic polymorphisms of de novo nucleotide biosynthesis with increased CHD susceptibility in the northern Chinese population.
  6. most significant association was detected for GART rs8971. Compared with individuals with the TT genotype, the age- and sex-adjusted odds ratio (OR) for developing HCC was 1.44 (95% confidence interval (CI): 1.03-2.02) among those with the CC genotype
    Title: Genetic variations in the one-carbon metabolism pathway genes and susceptibility to hepatocellular carcinoma risk: a case-control study.
  7. The current results showed that GART expression was associated with glioma grade and that high GART protein expression might be related to poor outcome.
    Title: Glycinamide ribonucleotide formyl transferase is frequently overexpressed in glioma and critically regulates the proliferation of glioma cells.
  8. our clinical and in vitro data indicate that GART expression may be one of the causative factors for a poor prognosis in hepatocellular carcinoma.
    Title: Increased expression of glycinamide ribonucleotide transformylase is associated with a poor prognosis in hepatocellular carcinoma, and it promotes liver cancer cell proliferation.
  9. High-resolution structural data for GART (transformylase domain; purN) reveal new binding mode for lipophilic diastereoisomer inhibitors of GART, folate analogs with anti-leukemic activity.
    Title: Biological and structural evaluation of 10R- and 10S-methylthio-DDACTHF reveals a new role for sulfur in inhibition of glycinamide ribonucleotide transformylase.
  10. Using the SNaPshot assay, evidence presented for allelic nondisjunction at rs363506 in the GRIK1 gene and rs2834235 and rs7283354 in the GARS-AIRS-GART gene in Down syndrome in India.
    Title: SNaPshot Assay in Quantitative Detection of Allelic Nondisjunction in Down Syndrome.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
EBI GWAS Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of GART PubMed

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif interacts with GART; interaction predicted to be relevant to purine pyrimidine biosynthesis PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC47764

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoribosylamine-glycine ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoribosylamine-glycine ligase activity TAS
Traceable Author Statement
more info
  
enables phosphoribosylformylglycinamidine cyclo-ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoribosylformylglycinamidine cyclo-ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoribosylformylglycinamidine cyclo-ligase activity TAS
Traceable Author Statement
more info
  
enables phosphoribosylglycinamide formyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoribosylglycinamide formyltransferase activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in 'de novo' AMP biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in 'de novo' IMP biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in 'de novo' IMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in 'de novo' XMP biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in GMP biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in adenine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in brainstem development IEA
Inferred from Electronic Annotation
more info
  
involved_in cerebellum development IEA
Inferred from Electronic Annotation
more info
  
involved_in cerebral cortex development IEA
Inferred from Electronic Annotation
more info
  
involved_in purine nucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in purine ribonucleoside monophosphate biosynthetic process TAS
Traceable Author Statement
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 

General protein information

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Preferred Names
trifunctional purine biosynthetic protein adenosine-3
Names
GAR transformylase
GARS-AIRS-GART
glycinamide ribonucleotide formyltransferase
glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide transformylase
NP_000810.1
NP_001129477.1
NP_001129478.1
NP_780294.1
XP_005260998.1
XP_006724052.1
XP_006724053.1
XP_011527828.1
XP_047296699.1
XP_054180407.1
XP_054180408.1
XP_054180409.1
XP_054180410.1
XP_054180411.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029160.2 RefSeqGene

    Range
    5776..43960
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000819.5 → NP_000810.1  trifunctional purine biosynthetic protein adenosine-3 isoform 1

    See identical proteins and their annotated locations for NP_000810.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1). Variants 1, 3, and 4 encode the same protein.
    Source sequence(s)
    AK292897, BQ010035, DB236855, X54199
    Consensus CDS
    CCDS13627.1
    UniProtKB/Swiss-Prot
    A8K945, A8KA32, D3DSF3, D3DSF4, O14659, P22102, Q52M77
    UniProtKB/TrEMBL
    Q3B7A7
    Related
    ENSP00000371236.4, ENST00000381815.9
    Conserved Domains (7) summary
    cd02196
    Location:469 → 767
    PurM; PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis. ...
    cd08645
    Location:809 → 991
    FMT_core_GART; Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART)
    PRK05385
    Location:435 → 766
    PRK05385; phosphoribosylaminoimidazole synthetase; Provisional
    TIGR00877
    Location:4 → 426
    purD; phosphoribosylamine--glycine ligase
    pfam01071
    Location:105 → 298
    GARS_A; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
    pfam02843
    Location:334 → 424
    GARS_C; Phosphoribosylglycinamide synthetase, C domain
    pfam02844
    Location:4 → 104
    GARS_N; Phosphoribosylglycinamide synthetase, N domain

  2. NM_001136005.1 → NP_001129477.1  trifunctional purine biosynthetic protein adenosine-3 isoform 1

    See identical proteins and their annotated locations for NP_001129477.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains a different segment for its 5' UTR, compared to variant 1. Variants 1, 3, and 4 encode the same protein.
    Source sequence(s)
    AK292560, AK292897, BM172468, BQ010035
    Consensus CDS
    CCDS13627.1
    UniProtKB/Swiss-Prot
    A8K945, A8KA32, D3DSF3, D3DSF4, O14659, P22102, Q52M77
    UniProtKB/TrEMBL
    Q3B7A7
    Related
    ENSP00000371253.3, ENST00000381831.7
    Conserved Domains (7) summary
    cd02196
    Location:469 → 767
    PurM; PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis. ...
    cd08645
    Location:809 → 991
    FMT_core_GART; Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART)
    PRK05385
    Location:435 → 766
    PRK05385; phosphoribosylaminoimidazole synthetase; Provisional
    TIGR00877
    Location:4 → 426
    purD; phosphoribosylamine--glycine ligase
    pfam01071
    Location:105 → 298
    GARS_A; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
    pfam02843
    Location:334 → 424
    GARS_C; Phosphoribosylglycinamide synthetase, C domain
    pfam02844
    Location:4 → 104
    GARS_N; Phosphoribosylglycinamide synthetase, N domain

  3. NM_001136006.1 → NP_001129478.1  trifunctional purine biosynthetic protein adenosine-3 isoform 1

    See identical proteins and their annotated locations for NP_001129478.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains a different segment for its 5' UTR, compared to variant 1. Variants 1, 3, and 4 encode the same protein.
    Source sequence(s)
    AB208785, AK292897, BQ010035, DB062974
    Consensus CDS
    CCDS13627.1
    UniProtKB/Swiss-Prot
    A8K945, A8KA32, D3DSF3, D3DSF4, O14659, P22102, Q52M77
    UniProtKB/TrEMBL
    Q3B7A7
    Related
    ENSP00000371261.3, ENST00000381839.7
    Conserved Domains (7) summary
    cd02196
    Location:469 → 767
    PurM; PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis. ...
    cd08645
    Location:809 → 991
    FMT_core_GART; Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART)
    PRK05385
    Location:435 → 766
    PRK05385; phosphoribosylaminoimidazole synthetase; Provisional
    TIGR00877
    Location:4 → 426
    purD; phosphoribosylamine--glycine ligase
    pfam01071
    Location:105 → 298
    GARS_A; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
    pfam02843
    Location:334 → 424
    GARS_C; Phosphoribosylglycinamide synthetase, C domain
    pfam02844
    Location:4 → 104
    GARS_N; Phosphoribosylglycinamide synthetase, N domain

  4. NM_175085.3 → NP_780294.1  trifunctional purine biosynthetic protein adenosine-3 isoform 2

    See identical proteins and their annotated locations for NP_780294.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is missing 3' end exons, compared to variant 1, which results in a shorter protein (isoform 2) compared to isoform 1.
    Source sequence(s)
    BC038958, BQ477393, DB236855
    Consensus CDS
    CCDS13628.1
    UniProtKB/TrEMBL
    Q15374
    Related
    ENSP00000354388.5, ENST00000361093.9
    Conserved Domains (4) summary
    TIGR00877
    Location:4 → 426
    purD; phosphoribosylamine--glycine ligase
    pfam01071
    Location:105 → 298
    GARS_A; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
    pfam02843
    Location:334 → 424
    GARS_C; Phosphoribosylglycinamide synthetase, C domain
    pfam02844
    Location:4 → 104
    GARS_N; Phosphoribosylglycinamide synthetase, N domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    33503931..33542893 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047440743.1 → XP_047296699.1  trifunctional purine biosynthetic protein adenosine-3 isoform X1

    UniProtKB/Swiss-Prot
    A8K945, A8KA32, D3DSF3, D3DSF4, O14659, P22102, Q52M77

  2. XM_006723990.3 → XP_006724053.1  trifunctional purine biosynthetic protein adenosine-3 isoform X1

    See identical proteins and their annotated locations for XP_006724053.1

    UniProtKB/Swiss-Prot
    A8K945, A8KA32, D3DSF3, D3DSF4, O14659, P22102, Q52M77
    UniProtKB/TrEMBL
    Q3B7A7
    Conserved Domains (7) summary
    cd02196
    Location:469 → 767
    PurM; PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis. ...
    cd08645
    Location:809 → 991
    FMT_core_GART; Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART)
    PRK05385
    Location:435 → 766
    PRK05385; phosphoribosylaminoimidazole synthetase; Provisional
    TIGR00877
    Location:4 → 426
    purD; phosphoribosylamine--glycine ligase
    pfam01071
    Location:105 → 298
    GARS_A; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
    pfam02843
    Location:334 → 424
    GARS_C; Phosphoribosylglycinamide synthetase, C domain
    pfam02844
    Location:4 → 104
    GARS_N; Phosphoribosylglycinamide synthetase, N domain

  3. XM_011529526.3 → XP_011527828.1  trifunctional purine biosynthetic protein adenosine-3 isoform X1

    See identical proteins and their annotated locations for XP_011527828.1

    UniProtKB/Swiss-Prot
    A8K945, A8KA32, D3DSF3, D3DSF4, O14659, P22102, Q52M77
    UniProtKB/TrEMBL
    Q3B7A7
    Conserved Domains (7) summary
    cd02196
    Location:469 → 767
    PurM; PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis. ...
    cd08645
    Location:809 → 991
    FMT_core_GART; Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART)
    PRK05385
    Location:435 → 766
    PRK05385; phosphoribosylaminoimidazole synthetase; Provisional
    TIGR00877
    Location:4 → 426
    purD; phosphoribosylamine--glycine ligase
    pfam01071
    Location:105 → 298
    GARS_A; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
    pfam02843
    Location:334 → 424
    GARS_C; Phosphoribosylglycinamide synthetase, C domain
    pfam02844
    Location:4 → 104
    GARS_N; Phosphoribosylglycinamide synthetase, N domain

  4. XM_006723989.3 → XP_006724052.1  trifunctional purine biosynthetic protein adenosine-3 isoform X1

    See identical proteins and their annotated locations for XP_006724052.1

    UniProtKB/Swiss-Prot
    A8K945, A8KA32, D3DSF3, D3DSF4, O14659, P22102, Q52M77
    UniProtKB/TrEMBL
    Q3B7A7
    Conserved Domains (7) summary
    cd02196
    Location:469 → 767
    PurM; PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis. ...
    cd08645
    Location:809 → 991
    FMT_core_GART; Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART)
    PRK05385
    Location:435 → 766
    PRK05385; phosphoribosylaminoimidazole synthetase; Provisional
    TIGR00877
    Location:4 → 426
    purD; phosphoribosylamine--glycine ligase
    pfam01071
    Location:105 → 298
    GARS_A; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
    pfam02843
    Location:334 → 424
    GARS_C; Phosphoribosylglycinamide synthetase, C domain
    pfam02844
    Location:4 → 104
    GARS_N; Phosphoribosylglycinamide synthetase, N domain

  5. XM_005260941.3 → XP_005260998.1  trifunctional purine biosynthetic protein adenosine-3 isoform X1

    See identical proteins and their annotated locations for XP_005260998.1

    UniProtKB/Swiss-Prot
    A8K945, A8KA32, D3DSF3, D3DSF4, O14659, P22102, Q52M77
    UniProtKB/TrEMBL
    Q3B7A7
    Conserved Domains (7) summary
    cd02196
    Location:469 → 767
    PurM; PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis. ...
    cd08645
    Location:809 → 991
    FMT_core_GART; Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART)
    PRK05385
    Location:435 → 766
    PRK05385; phosphoribosylaminoimidazole synthetase; Provisional
    TIGR00877
    Location:4 → 426
    purD; phosphoribosylamine--glycine ligase
    pfam01071
    Location:105 → 298
    GARS_A; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
    pfam02843
    Location:334 → 424
    GARS_C; Phosphoribosylglycinamide synthetase, C domain
    pfam02844
    Location:4 → 104
    GARS_N; Phosphoribosylglycinamide synthetase, N domain

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NW_003315970.2 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    108061..115588 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    31885765..31924746 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054324432.1 → XP_054180407.1  trifunctional purine biosynthetic protein adenosine-3 isoform X1

    UniProtKB/Swiss-Prot
    A8K945, A8KA32, D3DSF3, D3DSF4, O14659, P22102, Q52M77

  2. XM_054324433.1 → XP_054180408.1  trifunctional purine biosynthetic protein adenosine-3 isoform X1

    UniProtKB/Swiss-Prot
    A8K945, A8KA32, D3DSF3, D3DSF4, O14659, P22102, Q52M77

  3. XM_054324434.1 → XP_054180409.1  trifunctional purine biosynthetic protein adenosine-3 isoform X1

    UniProtKB/Swiss-Prot
    A8K945, A8KA32, D3DSF3, D3DSF4, O14659, P22102, Q52M77

  4. XM_054324436.1 → XP_054180411.1  trifunctional purine biosynthetic protein adenosine-3 isoform X1

    UniProtKB/Swiss-Prot
    A8K945, A8KA32, D3DSF3, D3DSF4, O14659, P22102, Q52M77

  5. XM_054324435.1 → XP_054180410.1  trifunctional purine biosynthetic protein adenosine-3 isoform X1

    UniProtKB/Swiss-Prot
    A8K945, A8KA32, D3DSF3, D3DSF4, O14659, P22102, Q52M77
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P22102.1 GenPept UniProtKB/Swiss-Prot:P22102

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